Profilin is required for viral morphogenesis, syncytium formation, and cell-specific stress fiber induction by respiratory syncytial virus

Abstract Background Actin is required for the gene expression and morphogenesis of respiratory syncytial virus (RSV), a clinically important Pneumovirus of the Paramyxoviridae family.In HEp-2 cells, RSV infection also induces actin stress fibers, which may be important in the immunopathology of the RSV disease.Profilin, a major regulator of actin p

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Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells

Background: Colorectal cancer (CRC) is a prevalent type of cancer, ranking third in incidence and fourth in cancer-related deaths globally.The increase in mortality rates related to colorectal cancer among younger patients is a cause for concern.Chemotherapy is the primary approach for palliative care in colon cancer, but the development of drug re

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